Synthesis and Structure–Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects

Published:2020-06-12 Issue:14 Volume:63 Page:7663-7694
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vekariya Rakesh H.¹,Lei Wei²,Ray Abhisek¹^ORCID,Saini Surendra K.¹,Zhang Sixue¹,Molnar Gabriella²,Barlow Deborah³,Karlage Kelly L.²,Bilsky Edward J.²,Houseknecht Karen L.³,Largent-Milnes Tally M.²,Streicher John M.²^ORCID,Ananthan Subramaniam¹^ORCID

Affiliation:

1. Chemistry Department, Southern Research, Birmingham, Alabama 35205, United States

2. Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States

3. Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005, United States

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00503