Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

Author:

Moritz Amy E.1,Free R. Benjamin1ORCID,Weiner Warren S.2,Akano Emmanuel O.1,Gandhi Disha3,Abramyan Ara4,Keck Thomas M.5ORCID,Ferrer Marc6,Hu Xin6,Southall Noel6,Steiner Joseph7,Aubé Jeffrey23ORCID,Shi Lei4,Frankowski Kevin J.23,Sibley David R.1ORCID

Affiliation:

1. Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, 35 Convent Drive, MSC-3723, Bethesda, Maryland 20892-3723, United States

2. University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, Kansas 66047, United States

3. Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States

4. Computational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland, 333 Cassell Drive, Baltimore, Maryland 21224, United States

5. Department of Chemistry & Biochemistry, Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States

6. NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

7. NeuroTherapeutics Development Unit, National Institute for Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, United States

Funder

National Institute of Neurological Disorders and Stroke

National Human Genome Research Institute

National Institute on Drug Abuse

Eshelman Institute for Innovation, University of North Carolina

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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