2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy-Reference-Cited by-同舟云学术

2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy

Published:2020-06-18 Issue:14 Volume:63 Page:7880-7891
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Babbs Arran¹,Berg Adam¹,Chatzopoulou Maria²^ORCID,Davies Kay E.¹,Davies Stephen G.²^ORCID,Edwards Benjamin¹,Elsey David J.³,Emer Enrico²,Guiraud Simon¹,Harriman Shawn³,Lecci Cristina⁴,Moir Lee¹,Peters David³,Robinson Neil⁵,Rowley Jessica A.²,Russell Angela J.²⁶^ORCID,Squire Sarah E.¹,Tinsley Jonathon M.³,Wilson Francis X.³,Wynne Graham M.²

Affiliation:

1. MDUK Oxford Neuromuscular Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, U.K.

2. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

3. Summit Therapeutics plc, 136a Eastern Avenue, Milton Park, Abingdon, Oxfordshire OX14 4SB, U.K.

4. Evotec (UK) Ltd, 114 Innovation Dr, Milton Park, Milton, Abingdon OX14 4RZ, U.K.

5. S.H.B. Enterprises Ltd, 55 Station Road, Beaconsfield HP19 1QL, U.K.

6. Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3PQ, U.K.

Funder

Medical Research Council

Duchenne UK

Summit Therapeutics plc

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00807

Reference24 articles.

1. Second-generation compound for the modulation of utrophin in the therapy of DMD

2. Pharmacological advances for treatment in Duchenne muscular dystrophy

3. The potential of utrophin modulators for the treatment of Duchenne muscular dystrophy

4. The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: an evidence review

5. Mutation-Based Therapeutic Strategies for Duchenne Muscular Dystrophy: From Genetic Diagnosis to Therapy

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