Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes-Reference-Cited by-同舟云学术

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

Published:2020-06-24 Issue:14 Volume:63 Page:7740-7765
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bell Andrew S.¹^ORCID,Yu Zhiyong¹,Hutton Jennie A.¹,Wright Megan H.²^ORCID,Brannigan James A.³^ORCID,Paape Daniel⁴,Roberts Shirley M.³,Sutherell Charlotte L.¹^ORCID,Ritzefeld Markus¹^ORCID,Wilkinson Anthony J.³,Smith Deborah F.⁴,Leatherbarrow Robin J.¹,Tate Edward W.¹^ORCID

Affiliation:

1. Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ

2. School of Chemistry, University of Leeds, Leeds, U.K. LS2 9JT

3. Structural Biology Laboratory, York Biomedical Research Institute, Department of Chemistry, University of York, York, U.K. YO10 5DD

4. Centre for Immunology and Infection, York Biomedical Research Institute, Department of Biology, University of York, York, U.K. YO10 5NG

Funder

Diamond Light Source

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00570

Reference46 articles.

1. Leishmaniasis: a review

2. WHO, Leishmaniasis. https://www.who.int/news-room/fact-sheets/detail/leishmaniasis (accessed 14 June, 2020).

3. Exploiting Knowledge on Leishmania Drug Resistance to Support the Quest for New Drugs

4. Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure

5. N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

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