Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold

Published:2020-06-12 Issue:14 Volume:63 Page:7817-7826
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ferguson Fleur M.¹^ORCID,Liu Yan²,Harshbarger Wayne²,Huang Ling³,Wang Jinhua¹,Deng Xianming¹^ORCID,Capuzzi Stephen J.⁴^ORCID,Muratov Eugene N.⁴^ORCID,Tropsha Alexander⁴^ORCID,Muthuswamy Senthil³⁵,Westover Kenneth D.²^ORCID,Gray Nathanael S.¹^ORCID

Affiliation:

1. Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States

2. Departments of Radiation Oncology and Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States

3. Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States

4. UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

5. Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts 02215, United States

Funder

National Cancer Institute

Welch Foundation

Bayer

American Cancer Society

Hale Center for Pancreatic Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine