Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere-Reference-Cited by-同舟云学术

Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere

Published:2020-07-24 Issue:15 Volume:63 Page:8534-8553
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rodríguez Sarmiento Rosa María¹^ORCID,Bissantz Caterina¹,Bylund Johan¹,Limberg Anja¹,Neidhart Werner¹,Jakob-Roetne Roland¹,Wang Lisha¹,Baumann Karlheinz¹

Affiliation:

1. Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00909

Reference27 articles.

1. Global prevalence of dementia: a Delphi consensus study

2. Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

3. Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

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