Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52-Reference-Cited by-同舟云学术

Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52

Published:2020-08-31 Issue:18 Volume:63 Page:10330-10338
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

de la Sierra-Gallay Inès Li¹,Belnou Mathilde²,Chambraud Béatrice³,Genet Melanie⁴,van Tilbeurgh Herman¹,Aumont-Nicaise Magali¹,Desmadril Michel¹,Baulieu Etienne-Emile⁴,Jacquot Yves⁵,Byrne Cillian²⁴^ORCID

Affiliation:

1. Institut de Biologie Intégrative de la Cellule (I2BC), CNRS UMR9198, Université Paris-Saclay, Université Paris-Sud, 91405 Orsay, France

2. Sorbonne Université, École normale supérieure, PSL University, CNRS, Laboratoire des biomolécules, LBM, 75005 Paris, France

3. INSERM UMR 1195, Université Paris XI, 94270 Le Kremlin Bicêtre, France

4. Institut Baulieu, INSERM UMR 1195, Neuroprotection et Neurorégénération, Université Paris-Saclay, 94270Le Kremlin Bicêtre, France

5. Cibles Thérapeutiques et Conception de Médicaments (CiTCoM), CNRS UMR 8038, INSERM U1268, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75270 Paris Cedex 06, France

Funder

Institut Baulieu, Le Kremlin Bic?tre

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00825

Reference36 articles.

1. The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

2. Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)

3. The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation

4. A role for FKBP52 in Tau protein function

5. The FK506-binding protein FKBP52in vitroinduces aggregation of truncated Tau forms with prion-like behavior