Synthesis and Biological Characterization of Cyclic Disulfide-Containing Peptide Analogs of the Multifunctional Opioid/Neuropeptide FF Receptor Agonists That Produce Long-Lasting and Nontolerant Antinociception

Author:

Zhang Mengna1,Xu Biao1,Li Ning1,Liu Hui2,Shi Xuerui1,Zhang Qinqin1,Shi Yanbin2,Xu Kangtai1,Xiao Jian1,Chen Dan1,Zhu Hanwen1,Sun Yulong3,Zhang Ting1,Zhang Run1,Fang Quan1ORCID

Affiliation:

1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China

2. School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China

3. Key Laboratory for Space Biosciences & Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710000, PR China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Gansu Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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