Mechanistic Insight into Antiretroviral Potency of 2′-Deoxy-2′-β-fluoro-4′-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention

Author:

Sun Li1,Peng Youmei2,Yu Wenquan3ORCID,Zhang Yan1,Liang Lan4,Song Chuanjun3ORCID,Hou Jiao3,Qiao Yan3ORCID,Wang Qingduan2,Chen Jingyu15,Wu Mengli15,Zhang Dongwei15,Li Ertong6,Han Zhifu6,Zhao Qingxia7,Jin Xia8,Zhang Bailing9,Huang Zhiwei9,Chai Jijie16,Wang Jian-Hua5,Chang Junbiao134ORCID

Affiliation:

1. Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, College of Life Science, Henan Normal University, Xinxiang 453007, China

2. Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

3. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

4. College of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

5. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

6. Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China

7. Department of Infection, Zhengzhou Sixth People’s Hospital, Zhengzhou 450000, China

8. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China

9. HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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