Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors-Reference-Cited by-同舟云学术

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Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors

Published:2020-03-26 Issue:8 Volume:63 Page:4256-4292
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thakur Ashish¹^ORCID,Tawa Gregory J.¹,Henderson Mark J.¹^ORCID,Danchik Carina¹,Liu Suiyang²,Shah Pranav¹,Wang Amy Q.¹,Dunn Garrett¹,Kabir Md¹,Padilha Elias C.¹,Xu Xin¹,Simeonov Anton¹,Kharbanda Surender²,Stone Richard²,Grewal Gurmit¹

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States

Funder

National Center for Advancing Translational Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00193

Reference73 articles.

1. Why is cancer drug discovery so difficult?

2. Hallmarks of Cancer: The Next Generation

3. Polypharmacology: Challenges and Opportunities in Drug Discovery

4. De Novo Design of Multitarget Ligands with an Iterative Fragment-Growing Strategy

5. Designed Multiple Ligands. An Emerging Drug Discovery Paradigm

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