Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice-Reference-Cited by-同舟云学术

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Published:2020-12-28 Issue:1 Volume:64 Page:812-839
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Viayna Elisabet¹,Coquelle Nicolas²³,Cieslikiewicz-Bouet Monika⁴,Cisternas Pedro⁵,Oliva Carolina A.⁵,Sánchez-López Elena⁶⁷,Ettcheto Miren⁷⁸⁹^ORCID,Bartolini Manuela¹⁰^ORCID,De Simone Angela¹¹,Ricchini Mattia¹,Rendina Marisa¹,Pons Mégane⁴,Firuzi Omidreza¹²,Pérez Belén¹³,Saso Luciano¹⁴,Andrisano Vincenza¹⁵^ORCID,Nachon Florian¹⁶,Brazzolotto Xavier¹⁶,García Maria Luisa⁶⁷,Camins Antoni⁷⁸,Silman Israel¹⁷,Jean Ludovic⁴^ORCID,Inestrosa Nibaldo C.⁵¹⁸,Colletier Jacques-Philippe²,Renard Pierre-Yves⁴^ORCID,Muñoz-Torrero Diego¹^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028 Barcelona, Spain

2. Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS UMR 5075, F-38054 Grenoble, France

3. Large Scale Structures Group, Institut Laue-Langevin, F-38042 Grenoble Cedex 9, France

4. Normandie University, UNIROUEN, INSA Rouen, CNRS, COBRA (UMR 6014), 76000 Rouen, France

5. Center of Aging and Regeneration UC (CARE-UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O’Higgins 340, P.O. Box 114, 8331150 Santiago, Chile

6. Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Av. Joan XXIII 27-31, E-08028 Barcelona, Spain

7. Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, E-28031 Madrid, Spain

8. Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Neuroscience, University of Barcelona, Av. Joan XXIII 27-31, E-08028 Barcelona, Spain

9. Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili, E-43201 Reus, Spain

10. Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy

11. Department of Drug Science and Technology, University of Turin, I-10125 Torino, Italy

12. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, PO Box 3288, 71345 Shiraz, Iran

13. Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, E-08193 Bellaterra, Barcelona, Spain

14. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy

15. Department for Life Quality Studies, University of Bologna, Corso d’Augusto 237, I-47921 Rimini, Italy

16. Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées BP73, 91993 Brétigny sur Orge, France

17. Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel

18. Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, 6200000 Punta Arenas, Chile

Funder

Agence Nationale de la Recherche

Ministry of Science, Innovation and Universities

Generalitat de Catalunya

Alzheimer Nadacn?? Fond

Fondo Nacional de Desarrollo Cient??fico y Tecnol??gico

MIADES

Ministero dell'Istruzione, dell'Universit?? e della Ricerca

Agencia Estatal de Investigaci??n

FEDER

Basal Center of Excellence in Aging and Regeneration

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01775

Reference101 articles.

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5. Structure-Based Survey of the Binding Modes of BACE1 Inhibitors

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