Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase-Reference-Cited by-同舟云学术

Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

Published:2020-04-22 Issue:9 Volume:63 Page:4908-4928
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Mei-Xin¹^ORCID,Yang Yiqing²^ORCID,Zhao Qiuye²,Wu Yue²,Song Lei³,Yang Haiyan⁴,He Ming²,Gao Hongying²,Song Bao-Liang¹,Luo Jie¹,Rao Yu²^ORCID

Affiliation:

1. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, P.R. China

2. MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, P.R. China

3. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences PHOENIX Center, Beijing Institute of LifeOmics, Beijing 102206, P.R. China

4. School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China

Funder

Ministry of Science and Technology of the People's Republic of China

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00339

Reference67 articles.