Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K)-Reference-Cited by-同舟云学术

Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K)

Published:2015-09-10 Issue:18 Volume:58 Page:7431-7448
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lawhorn Brian G.¹,Philp Joanne¹,Zhao Yongdong¹,Louer Christopher¹,Hammond Marlys¹,Cheung Mui¹,Fries Harvey¹,Graves Alan P.¹,Shewchuk Lisa¹,Wang Liping¹,Cottom Joshua E.¹,Qi Hongwei¹,Zhao Huizhen¹,Totoritis Rachel¹,Zhang Guofeng¹,Schwartz Benjamin¹,Li Hu¹,Sweitzer Sharon¹,Holt Dennis A.¹,Gatto Gregory J.¹,Kallander Lara S.¹

Affiliation:

1. Heart Failure Discovery Performance Unit and ‡Platform Technology and Sciences, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00931

Reference51 articles.

1. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I

2. Troponin I-Interacting Protein Kinase

3. Inhibition of the Cardiomyocyte-Specific Kinase TNNI3K Limits Oxidative Stress, Injury, and Adverse Remodeling in the Ischemic Heart

4. Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy

5. Tnni3k Modifies Disease Progression in Murine Models of Cardiomyopathy

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