Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues-Reference-Cited by-同舟云学术

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues

Published:2015-09-02 Issue:18 Volume:58 Page:7409-7418
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bockus Andrew T.¹,Schwochert Joshua A.¹,Pye Cameron R.¹,Townsend Chad E.¹,Sok Vong¹,Bednarek Maria A.²,Lokey R. Scott¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States

2. Department of Antibody Discovery & Protein Engineering, Medimmune Ltd, Cambridge CB21 6GH, United Kingdom

Funder

MedImmune

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00919

Reference55 articles.

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2. The Future of Peptide-based Drugs

3. Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

4. Macrocycles: lessons from the distant past, recent developments, and future directions

5. How Structural Features Influence the Biomembrane Permeability of Peptides

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