The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits-Reference-Cited by-同舟云学术

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

Published:2015-07-02 Issue:18 Volume:58 Page:7140-7163
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bertrand Sophie M.¹²,Ancellin Nicolas³,Beaufils Benjamin³,Bingham Ryan P.¹,Borthwick Jennifer A.¹²,Boullay Anne-Bénédicte³,Boursier Eric³,Carter Paul S.¹,Chung Chun-wa¹,Churcher Ian¹,Dodic Nerina³,Fouchet Marie-Hélène³,Fournier Charlène¹,Francis Peter L.¹,Gummer Laura A.¹,Herry Kenny³,Hobbs Andrew¹,Hobbs Clare I.¹,Homes Paul¹,Jamieson Craig²,Nicodeme Edwige³,Pickett Stephen D.¹,Reid Iain H.¹,Simpson Graham L.¹,Sloan Lisa A.¹,Smith Sarah E.¹,Somers Donald O’N.¹,Spitzfaden Claus¹,Suckling Colin J.²,Valko Klara¹,Washio Yoshiaki¹,Young Robert J.¹

Affiliation:

1. GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

2. Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, U.K.

3. Centre de Recherche, GlaxoSmithKline R&D, Les Ulis, 25, 27 Avenue du Québec, 91140 Villebon sur Yvette, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00313

Reference62 articles.

1. Structure and function of branched chain aminotransferases