Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors

Published:2015-06-12 Issue:12 Volume:58 Page:5028-5037
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Green Jeremy¹,Cao Jingrong¹,Bandarage Upul K.¹,Gao Huai¹,Court John¹,Marhefka Craig¹,Jacobs Marc¹,Taslimi Paul¹,Newsome David¹,Nakayama Tomoko¹,Shah Sundeep²,Rodems Steve²

Affiliation:

1. Vertex Pharmaceuticals, Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States

2. Vertex Pharmaceuticals, Inc., 11010 Torreyana Road, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00424

Reference43 articles.

1. ROCKs: multifunctional kinases in cell behaviour

2. The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity

3. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

4. Role of rho kinase in the functional and dysfunctional tonic smooth muscles

5. Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

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