Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C-21-Reference-Cited by-同舟云学术

Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C-21

Published:2015-04-14 Issue:8 Volume:58 Page:3500-3511
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Martinez Botella Gabriel¹,Salituro Francesco G.¹,Harrison Boyd L.¹,Beresis Richard T.²,Bai Zhu³,Shen Kaisheng²,Belfort Gabriel M.¹,Loya Carlos M.¹,Ackley Michael A.¹,Grossman Scott J.¹,Hoffmann Ethan¹,Jia Shiling²,Wang Jiamiao²,Doherty James J.¹,Robichaud Albert J.¹

Affiliation:

1. SAGE Therapeutics, 215 First Street, Cambridge, Massachusetts 02142, United States

2. Shanghai Chempartner, 998 Halei Road, Shanghai, China 201203

3. WuXi AppTec, 288 Fute Zhong Road, Shanghai, China 200131

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00032

Reference49 articles.

1. Interaction of Steroids with the GABA-A Receptor