Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma-Reference-Cited by-同舟云学术

Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

Published:2016-02-10 Issue:5 Volume:59 Page:1711-1726
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Biggadike Keith¹,Ahmed Mahbub¹,Ball Doug I.¹,Coe Diane M.¹,Dalmas Wilk Deidre A.²,Edwards Chris D.¹,Gibbon Bob H.³,Hardy Charlotte J.¹,Hermitage Stephen A.¹,Hessey Joanne O.¹,Hillegas Aimee E.²,Hughes Stephen C.³,Lazarides Linos¹,Lewell Xiao Q.¹,Lucas Amanda¹,Mallett David N.¹,Price Mark A.³,Priest Fiona M.¹,Quint Diana J.¹,Shah Poonam¹,Sitaram Anesh³,Smith Stephen A.¹,Stocker Richard¹,Trivedi Naimisha A.¹,Tsitoura Daphne C.¹,Weller Victoria¹

Affiliation:

1. GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

2. GlaxoSmithKline R&D, UpperMerion, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

3. GlaxoSmithKline R&D, David Jack Centre, Park Road, Ware, Hertfordshire SG12 ODP, U.K.

Funder

GlaxoSmithKline

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01647