4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA–PB1 Protein–Protein Interaction: Structure–Activity Relationships Exploration with the Aid of Molecular Modeling

Author:

Trist Iuni M. L.1,Nannetti Giulio2,Tintori Cristina1,Fallacara Anna Lucia1,Deodato Davide1,Mercorelli Beatrice2,Palù Giorgio2,Wijtmans Maikel3,Gospodova Tzveta4,Edink Ewald3,Verheij Mark3,de Esch Iwan3,Viteva Lilia4,Loregian Arianna2,Botta Maurizio15

Affiliation:

1. Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. Moro, I-53100 Siena, Italy

2. Dipartimento di Medicina Molecolare, Università degli Studi di Padova, Via A. Gabelli 63, I-35121 Padova, Italy

3. Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

4. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. Georgy Bonchev str. BI. 9, 1113 Sofia, Bulgaria

5. Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, United States

Funder

Universit? degli Studi di Padova

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference57 articles.

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