Bifunctional Peptide-Based Opioid Agonist–Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

Author:

Guillemyn Karel1,Starnowska Joanna2,Lagard Camille3,Dyniewicz Jolanta4,Rojewska Ewelina2,Mika Joanna2,Chung Nga N.5,Utard Valérie6,Kosson Piotr4,Lipkowski Andrzej W.4,Chevillard Lucie3,Arranz-Gibert Pol7,Teixidó Meritxell7,Megarbane Bruno3,Tourwé Dirk1,Simonin Frédéric6,Przewlocka Barbara2,Schiller Peter W.5,Ballet Steven1

Affiliation:

1. Research Group of Organic Chemistry, Departments of Chemistry and Bio-engineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium

2. Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland

3. Assistance Publique—Hôpitaux de Paris, Hôpital Lariboisière, Réanimation Médicale et Toxicologique, Inserm U1144, Université Paris Descartes UMR-S 1144, Université Paris Didero, UMR-S 1144, Paris, France

4. Neuropeptide Laboratory, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, PL 02-106 Warsaw, Poland

5. Department of Chemical Biology and Peptide Research, Clinical Research Institute, 110 Avenue Des Pins Ouest, Montreal, Quebec H2W 1R7, Canada

6. University of Strasbourg, CNRS, UMR7242, ESBS, 67412 Illkirch-Graffenstaden, France

7. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, 08028 Barcelona, Spain

Funder

Ministerstwo Nauki i Szkolnictwa Wyzszego

Agence Nationale de la Recherche

Université de Strasbourg

Ministerio de Economía y Competitividad

Narodowe Centrum Nauki

Centre National de la Recherche Scientifique

European Regional Development Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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