Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their <i>In Vivo</i> Delivery to the Skin-Reference-Cited by-同舟云学术

Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin

Published:2022-06-02 Issue:14 Volume:65 Page:9735-9749
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gonschorek Patrick¹^ORCID,Zorzi Alessandro¹,Maric Tamara¹,Le Jeune Mathilde¹,Schüttel Mischa¹,Montagnon Mathilde¹,Gómez-Ojea Rebeca¹,Vollmar Denis Patrick¹,Whitfield Chantal¹,Reymond Luc²,Carle Vanessa¹,Verma Hitesh¹,Schilling Oliver³^ORCID,Hovnanian Alain⁴,Heinis Christian¹^ORCID

Affiliation:

1. Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland

2. Biomolecular Screening Facility, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne CH-1015, Switzerland

3. Institute for Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany

4. INSERM UMR1163, Imagine Institute, University of Paris, Paris, France; Department of Genetics, Necker Hospital for Sick Children (AP-HP), 75015 Paris, France

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Horizon 2020 Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00306

Reference33 articles.

1. hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6

2. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome

3. Advances in understanding of Netherton syndrome and therapeutic implications

4. KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype

5. KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome

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