Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

Published:2023-05-03 Issue:10 Volume:66 Page:6652-6681
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Skácel Jan¹,Djukic Stefan¹,Baszczyňski Ondřej¹²,Kalčic Filip¹^ORCID,Bílek Tadeáš¹,Chalupský Karel¹,Kozák Jaroslav¹,Dvořáková Alexandra¹,Tloušt’ová Eva¹,Král’ová Zuzana¹²,Šmídková Markéta¹,Voldřich Jan¹³,Rumlová Michaela³,Pachl Petr¹,Brynda Jiří¹,Vučková Tereza¹,Fábry Milan¹⁴,Snášel Jan¹,Pichová Iva¹,Řezáčová Pavlína¹,Mertlíková-Kaiserová Helena¹,Janeba Zlatko¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic

2. Faculty of Science, Charles University in Prague, Hlavova 2030/8, Prague 2 12843, Czech Republic

3. University of Chemistry and Technology, Technická 5, Prague 16628, Czech Republic

4. Institute of Molecular Genetics, The Czech Academy of Science, Vídeňská 1083, Prague 14220, Czech Republic

Funder

Technology Agency of the Czech Republic

European Commission

European Regional Development Fund

Akademie Ved Cesk? Republiky

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c02097

Reference66 articles.

1. Enzymes of the Purine Metabolism: Inhibition and Therapeutic Potential

2. Purine nucleoside phosphorylase: A target for drug design

3. Purine Nucleoside Phosphorylase from Human Erythrocytes

4. Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis. Analysis of Inhibition by a Transition-State Analogue and Dissection by Parts

5. Crystallographic structure of PNP from Mycobacterium tuberculosis at 1.9Å resolution

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