Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization
Author:
Affiliation:
1. Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21701-4907, United States
Funder
Vanderbilt University
National Cancer Institute
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00195
Reference50 articles.
1. The WD repeat: a common architecture for diverse functions
2. WD40 proteins propel cellular networks
3. Structure and function of WD40 domain proteins
4. Moonlighting with WDR5: A Cellular Multitasker
5. Molecular recognition of histone H3 by the WD40 protein WDR5
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