Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2

Author:

Yu Wenying1ORCID,Zhao Yucheng2,Ye Hui13ORCID,Wu Nanping45,Liao Yixian1,Chen Nannan1,Li Zhiling1,Wan Ning13,Hao Haiping13,Yan Honggao16,Xiao Yibei16,Lai Maode147ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing210009, China

2. Department of Resources Science of Traditional Chinese Medicines and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing210009, China

3. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing210009, China

4. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Zhejiang University, Hangzhou310003, China

5. First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, China

6. Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing310003, China

7. School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing210009, China

Funder

Chinesisch-Deutsche Zentrum f?r Wissenschaftsf?rderung

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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