Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides-Reference-Cited by-同舟云学术

Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides

Published:2022-07-29 Issue:15 Volume:65 Page:10655-10673
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yoshida Shuhei¹^ORCID,Uehara Shota¹^ORCID,Kondo Noriyasu¹,Takahashi Yu¹,Yamamoto Shiho¹^ORCID,Kameda Atsushi¹,Kawagoe Soichiro¹,Inoue Naoko²,Yamada Masami²,Yoshimura Norito¹,Tachibana Yuki¹^ORCID

Affiliation:

1. Pharmaceutical Research Division, Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka561-0825, Japan

2. PeptiDream Inc.3-25-23 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa210-0821, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00919

Reference68 articles.

1. Where Do Recent Small Molecule Clinical Development Candidates Come From?

2. Twenty years on: the impact of fragments on drug discovery

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4. DNA-Encoded Library Screening as Core Platform Technology in Drug Discovery: Its Synthetic Method Development and Applications in DEL Synthesis

5. Drugging challenging targets using fragment-based approaches

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