Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis-Reference-Cited by-同舟云学术

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis

Published:2022-12-05 Issue:24 Volume:65 Page:16290-16312
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Craig Robert A.¹^ORCID,Fox Brian M.¹,Hu Cheng¹,Lexa Katrina W.¹,Osipov Maksim¹,Thottumkara Arun P.¹,Larhammar Martin¹^ORCID,Miyamoto Takashi¹,Rana Anil¹,Kane Lesley A.¹,Yulyaningsih Ernie¹^ORCID,Solanoy Hilda¹,Nguyen Hoang¹,Chau Roni¹,Earr Timothy¹,Kajiwara Yuji¹^ORCID,Fleck Daniel¹,Lucas Anthony¹,Haddick Patrick C. G.¹,Takahashi Ryan H.¹,Tong Vincent¹,Wang Jing¹,Canet Mark J.¹,Poda Suresh B.¹,Scearce-Levie Kimberly¹,Srivastava Ankita¹,Sweeney Zachary K.¹^ORCID,Xu Musheng²,Zhang Rui²,He Jianrong²,Lei Yanan²,Zhuo Zheng²,de Vicente Javier¹^ORCID

Affiliation:

1. Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States

2. Department of Chemistry, WuXi AppTec Co., Ltd., 168 Nanhai Road, 10th Avenue, Tianjin TEDA, Tianjin 300457, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01056

Reference29 articles.

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