Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3-Reference-Cited by-同舟云学术

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3

Published:2022-08-15 Issue:16 Volume:65 Page:11084-11099
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Chunjian¹^ORCID,Jalagam Prasada Rao²,Feng Jianxin¹,Wang Wei¹,Raja Thiruvenkadam²,Sura Mallikarjuna Reddy²,Manepalli Raju K. V. L. P.²,Aliphedi Bheema Reddy²,Medavarapu Santosh²,Nair Satheesh K.²,Muthalagu Vetrichelvan²^ORCID,Natesan Ramesh²,Gupta Anuradha²^ORCID,Beno Brett³,Panda Manoranjan²,Ghosh Kaushik²,Shukla Jinal Kaushikkumar²,Sale Harinath²,Haldar Priyanka²,Kalidindi Narasimharaju²,Shah Devang²,Patel Dipal⁴,Mathur Arvind⁵,Ellsworth Bruce A.¹^ORCID,Cheng Dong⁶,Regueiro-Ren Alicia¹^ORCID

Affiliation:

1. Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States

2. Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India

3. Department of Computer-Aided Drug Design & Molecular Analytics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States

4. Department of Metabolism and Pharmacokinetics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States

5. Department of Discovery Synthesis, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States

6. Department of Cardiovascular and Fibrosis Discovery Biology, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00517

Reference43 articles.

1. Galectins: A family of animal β-galactoside-binding lectins

2. Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution

3. Galectin-3: An open-ended story

4. The family of metazoan metal-independent β-galactoside-binding lectins: structure, function and molecular evolution

5. Galectins: A Family of Animal Lectins That Decipher Glycocodes

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