X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor
Author:
Affiliation:
1. Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, United Kingdom
Funder
Astex Pharmaceuticals
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01044
Reference58 articles.
1. An overview of kinase downregulators and recent advances in discovery approaches
2. Covalent Small Molecules as Enabling Platforms for Drug Discovery
3. Fragment-based covalent ligand discovery
4. Drugging the 'undruggable' cancer targets
5. Electrophilic warheads in covalent drug discovery: an overview
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