Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS<sup>G12C</sup>-Reference-Cited by-同舟云学术

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS^G12C

Published:2022-04-26 Issue:9 Volume:65 Page:6940-6952
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kettle Jason G.¹^ORCID,Bagal Sharan K.¹,Bickerton Sue¹,Bodnarchuk Michael S.¹^ORCID,Boyd Scott¹,Breed Jason²,Carbajo Rodrigo J.¹^ORCID,Cassar Doyle J.¹^ORCID,Chakraborty Atanu¹,Cosulich Sabina¹,Cumming Iain¹,Davies Michael¹,Davies Nichola L.¹,Eatherton Andrew¹,Evans Laura¹,Feron Lyman¹,Fillery Shaun¹^ORCID,Gleave Emma S.²,Goldberg Frederick W.¹^ORCID,Hanson Lyndsey³,Harlfinger Stephanie¹,Howard Martin¹,Howells Rachel¹,Jackson Anne²,Kemmitt Paul¹,Lamont Gillian¹,Lamont Scott¹,Lewis Hilary J.¹^ORCID,Liu Libin⁴,Niedbala Michael J.⁵,Phillips Christopher²,Polanski Radek²,Raubo Piotr¹,Robb Graeme¹^ORCID,Robinson David M.¹,Ross Sarah¹,Sanders Matthew G.¹,Tonge Michael²,Whiteley Rebecca¹,Wilkinson Stephen¹,Yang Junsheng⁴,Zhang Wenman⁴

Affiliation:

1. Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

2. Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

3. Oncology R&D, AstraZeneca, Alderley Park SK10 4TG, U.K.

4. Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, P. R. China

5. Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00369