Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein–Protein Interaction Sites-Reference-Cited by-同舟云学术

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Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein–Protein Interaction Sites

Published:2022-10-19 Issue:21 Volume:65 Page:14630-14641
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Barthel Tatjana¹,Wollenhaupt Jan¹^ORCID,Lima Gustavo M. A.²^ORCID,Wahl Markus C.¹³,Weiss Manfred S.¹^ORCID

Affiliation:

1. Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Straße 15, 12489 Berlin, Germany

2. MAX IV Laboratory, BioMAX, Fotongatan 2, 224 84 Lund, Sweden

3. Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany

Funder

Svenska Forskningsr?det Formas

VINNOVA

H2020 Research Infrastructures

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01165

Reference61 articles.

1. Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

2. Twenty years on: the impact of fragments on drug discovery

3. How many drug targets are there?

4. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

5. Trends in kinase drug discovery: targets, indications and inhibitor design

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