Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors’ Binding Pocket-Reference-Cited by-同舟云学术

Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors’ Binding Pocket

Published:2023-01-26 Issue:3 Volume:66 Page:2102-2115
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhao Fabao¹,Zhang Heng¹,Xie Minghui¹,Meng Bairu¹,Liu Na¹,Dun Caiyun¹,Qin Yanyang¹,Gao Shenghua¹,De Clercq Erik²^ORCID,Pannecouque Christophe²,Tang Ya-Jie³^ORCID,Zhan Peng¹⁴^ORCID,Liu Xinyong¹⁴^ORCID,Kang Dongwei¹⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012 Shandong, PR China

2. Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), Leuven B-3000, Belgium

3. State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China

4. China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, Jinan 250012 Shandong, PR China

Funder

Taishan Scholar Project of Shandong Province

Shandong University

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01875

Reference23 articles.

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2. Projected life expectancy of people with HIV according to timing of diagnosis

3. Mortality in the Highly Active Antiretroviral Therapy Era

4. Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

5. The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic

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