Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

Author:

Alhayek Alaa12,Abdelsamie Ahmed S.13,Schönauer Esther4,Camberlein Virgyl1,Hutterer Evelyn4ORCID,Posselt Gernot4,Serwanja Jamil4,Blöchl Constantin4,Huber Christian G.4,Haupenthal Jörg1,Brandstetter Hans4,Wessler Silja4,Hirsch Anna K. H.12ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany

2. Department of Pharmacy, Saarland University, Campus Building C2. 3, 66123 Saarbrücken, Germany

3. Department of Chemistry of Natural and Microbial Products, Institute of Pharmaceutical and Drug Industries Research, National Research Centre, El-Buhouth St., Dokki, 12622 Cairo, Egypt

4. Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria

Funder

Austrian Science Fund

Helmholtz Association

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference52 articles.

1. Antibiotic resistance. https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. (accessed Feb 13, 2022).

2. No Time to Wait: Securing the Future from Drug-Resistant Infections. https://www.who.int/publications/i/item/no-time-to-wait-securing-the-future-from-drug-resistant-infections. (accessed Feb 13, 2022).

3. Limiting Damage during Infection: Lessons from Infection Tolerance for Novel Therapeutics

4. Targeting virulence: can we make evolution-proof drugs?

5. Drug repurposing for antimicrobial discovery

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