Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease <i>In Vivo</i>-Reference-Cited by-同舟云学术

Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease In Vivo

Published:2022-05-10 Issue:10 Volume:65 Page:7334-7362
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yan Yaoyao¹,Xing Chen¹,Xiao Yun¹,Shen Xiaobao²,Zhang Zhaoyan¹,He Chuanbiao¹,Shi Jing-Bo¹,Liu Mingming¹,Liu Xinhua¹^ORCID

Affiliation:

1. School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China

2. School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, P. R. China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00356

Reference39 articles.

1. Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments

2. Crohn's disease

3. Ulcerative colitis: towards remission

4. Epidemiology and Pathogenesis of Ulcerative Colitis

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