Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis-Reference-Cited by-同舟云学术

Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis

Published:2022-06-13 Issue:12 Volume:65 Page:8303-8331
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Frankowski Kevin J.¹²^ORCID,Patnaik Samarjit³^ORCID,Wang Chen⁴,Southall Noel³^ORCID,Dutta Dipannita³,De Soumitta⁵,Li Dandan⁵,Dextras Christopher³,Lin Yi-Han³,Bryant-Connah Marthe³,Davis Danielle³,Wang Feijun²,Wachsmuth Leah M.³,Shah Pranav³,Williams Jordan³,Kabir Md³,Zhu Edward³,Baljinnyam Bolormaa³,Wang Amy³,Xu Xin³,Norton John⁴,Ferrer Marc³,Titus Steve³,Simeonov Anton³,Zheng Wei³,Mathews Griner Lesley A.³,Jadhav Ajit³,Aubé Jeffrey¹²^ORCID,Henderson Mark J.³^ORCID,Rudloff Udo⁵,Schoenen Frank J.¹,Huang Sui⁴,Marugan Juan J.³^ORCID

Affiliation:

1. KU Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States

2. Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

3. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

4. Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois 60611, United States

5. Rare Tumor Initiative, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, United States

Funder

National Center for Advancing Translational Sciences

National Human Genome Research Institute

National Institute of Mental Health

Eshelman Institute for Innovation, University of North Carolina

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00204

Reference35 articles.