Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation

Author:

Bayrak Alp1ORCID,Mohr Florian1,Kolb Kyra2,Szpakowska Martyna3ORCID,Shevchenko Ekaterina4,Dicenta Valerie2ORCID,Rohlfing Anne-Katrin2,Kudolo Mark1,Pantsar Tatu15ORCID,Günther Marcel1,Kaczor Agnieszka A.56ORCID,Poso Antti54ORCID,Chevigné Andy3ORCID,Pillaiyar Thanigaimalai1ORCID,Gawaz Meinrad2,Laufer Stefan A.1ORCID

Affiliation:

1. Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

2. Department of Internal Medicine III, Cardiology and Angiology, University Hospital Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany

3. Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg

4. Department of Internal Medicine VIII, Oncology and Pneumology, University Hospital Tübingen, Otfried-Müller-Strasse 14, 72076 Tübingen, Germany

5. School of Pharmacy, University of Eastern Finland, P.O. BOX 1627, 70211 Kuopio, Finland

6. Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093 Lublin, Poland

Funder

Bundesministerium f?r Bildung und Forschung

Orionin Tutkimuss??ti?

Fonds National de la Recherche Luxembourg

Deutsche Forschungsgemeinschaft

Fonds De La Recherche Scientifique - FNRS

Ministerium f?r Wissenschaft, Forschung und Kunst Baden-W?rttemberg

CSC - IT Center for Science

Luxembourg Institute of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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