Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology

Author:

Macabuag Natsuko1,Esmieu William1,Breccia Perla1ORCID,Jarvis Rebecca1,Blackaby Wesley1,Lazari Ovadia1,Urbonas Liudvikas1,Eznarriaga Maria1,Williams Rachel1,Strijbosch Annelieke2,Van de Bospoort Rhea2,Matthews Kim1,Clissold Cole1,Ladduwahetty Tammy1,Vater Huw1ORCID,Heaphy Patrick3,Stafford Douglas G.3,Wang Hong-Jun3,Mangette John E.3,McAllister George4,Beaumont Vahri4,Vogt Thomas F.4,Wilkinson Hilary A.4,Doherty Elizabeth M.4,Dominguez Celia4

Affiliation:

1. Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.

2. Charles River, Darwinweg 24, Leiden 2333 CR, The Netherlands

3. Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States

4. CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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