Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates-Reference-Cited by-同舟云学术

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

Published:2022-12-07 Issue:24 Volume:65 Page:16234-16251
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mandal Mihirbaran¹^ORCID,Xiao Li²,Pan Weidong¹,Scapin Giovanna²,Li Guoqing¹,Tang Haiqun¹,Yang Shu-Wei¹,Pan Jianping¹,Root Yuriko¹,de Jesus Reynalda Keh¹,Yang Christine¹,Prosise Winnie²,Dayananth Priya³,Mirza Asra⁴,Therien Alex G.⁴,Young Katherine⁴,Flattery Amy⁵,Garlisi Charles³,Zhang Rumin³,Chu Donald³,Sheth Payal³,Chu Inhou⁶,Wu Jin⁶,Markgraf Carrie⁷,Kim Hai-Young²,Painter Ronald³,Mayhood Todd W.³,DiNunzio Edward³,Wyss Daniel F.²,Buevich Alexei V.⁸^ORCID,Fischmann Thierry²,Pasternak Alexander¹,Dong Shuzhi¹,Hicks Jacqueline D.¹,Villafania Artjohn³,Liang Lianzhu⁵,Murgolo Nicholas⁴,Black Todd⁴,Hagmann William K.¹,Tata Jim¹,Parmee Emma R.¹,Weber Ann E.¹,Su Jing¹,Tang Haifeng¹

Affiliation:

1. Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

2. Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

3. In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

4. Antibacterial/antifungal, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

5. In vivo biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

6. Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

7. Nonclinical Drug Safety, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

8. Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey07033, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00766

Reference51 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

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