BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe-Reference-Cited by-同舟云学术

BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe

Published:2022-10-19 Issue:21 Volume:65 Page:14366-14390
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Günther Judith¹^ORCID,Hillig Roman C.¹,Zimmermann Katja²,Kaulfuss Stefan¹,Lemos Clara¹,Nguyen Duy¹,Rehwinkel Hartmut¹,Habgood Matthew³,Lechner Christian¹,Neuhaus Roland¹,Ganzer Ursula¹,Drewes Mark⁴,Chai Jijie⁵,Bouché Léa¹^ORCID

Affiliation:

1. Research & Development, Pharmaceuticals, Bayer Pharma AG, Müllerstrasse 178, 13353Berlin, Germany

2. Research & Development, Pharmaceuticals, Bayer Pharma AG, Aprather Weg 18a, 42113Wuppertal, Germany

3. Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, OxfordshireOX14 4RZ, U.K.

4. Research & Development BCS, Bayer AG, Alfred-Nobel-Strasse 50, 40789Monheim, Germany

5. School of Life Sciences, Tsinghua University, 100084Beijing, China

Funder

Bayer

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00441

Reference65 articles.

1. Branched-Chain Amino Acid Metabolism

2. Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves

3. Brain metabolism of branched-chain amino acids

4. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

5. The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fueling the fight against cancer: Exploring the impact of branched-chain amino acid catalyzation on cancer and cancer immune microenvironment;Metabolism;2024-12

2. Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation;Signal Transduction and Targeted Therapy;2024-08-15

3. MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes;Nature Cell Biology;2024-06-05

4. Synthesis of Pyrimido[1,2-a]indolediones and Pyrimidinediones via [4+2] Annulation of 2H-Azirine-2-carbaldehydes;The Journal of Organic Chemistry;2024-04-25

5. Integrative Multi-omics Analysis Reveals Different Metabolic Phenotypes Based on Molecular Characteristics in Thyroid Cancer;Clinical Cancer Research;2024-01-09