Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors
Author:
Affiliation:
1. Merck Healthcare KGaA, Frankfurter Str. 250, 64293Darmstadt, Germany
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00851
Reference24 articles.
1. Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease
2. Current clinical management of gastrointestinal stromal tumors
3. Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications
4. Antonescu, C. R. The GIST Paradigm: Lessons for Other Kinase-Driven Cancers; John Wiley and Sons Ltd: 2011; Vol. 223, pp 252–262.
5. Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate At Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033
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1. Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review;Bioorganic Chemistry;2023-11
2. Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR);International Journal of Molecular Sciences;2023-05-29
3. Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST);Clinical Cancer Research;2023-05-24
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