Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer-Reference-Cited by-同舟云学术

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

Published:2019-11-13 Issue:2 Volume:63 Page:512-528
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

El-Ahmad Youssef^ORCID,Tabart Michel,Halley Frank,Certal Victor,Thompson Fabienne,Filoche-Rommé Bruno,Gruss-Leleu Florence,Muller Claire,Brollo Maurice,Fabien Laurence,Loyau Véronique,Bertin Luc,Richepin Patrick,Pilorge Fabienne,Desmazeau Pascal,Girardet Chrystelle,Beccari Sylvie,Louboutin Audrey,Lebourg Gilles,Le-Roux Jacques,Terrier Corinne,Vallée François,Steier Valérie,Mathieu Magali,Rak Alexey,Abecassis Pierre-Yves,Vicat Pascale,Benard Tsiala,Bouaboula Monsif¹,Sun Fangxian¹,Shomali Maysoun¹,Hebert Andrew¹,Levit Mikhail¹,Cheng Hong¹,Courjaud Albane,Ginesty Celine,Perrault Christelle,Garcia-Echeverria Carlos,McCort Gary,Schio Laurent

Affiliation:

1. Oncology, Sanofi, 640 Memorial Drive, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01293

Reference39 articles.

1. New Global Cancer Data: GLOBOCAN 2018; World Health Organization, 2018. https://www.uicc.org/new-global-cancer-data-globocan-2018.

2. Biological subtypes of breast cancer: Prognostic and therapeutic implications

3. Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential