Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer
Author:
Affiliation:
1. Oncology, Sanofi, 640 Memorial Drive, Cambridge, Massachusetts 02139, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01293
Reference39 articles.
1. New Global Cancer Data: GLOBOCAN 2018; World Health Organization, 2018. https://www.uicc.org/new-global-cancer-data-globocan-2018.
2. Biological subtypes of breast cancer: Prognostic and therapeutic implications
3. Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential
4. ecancermedicalscience
5. The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer
Cited by 49 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Hot-Spot Residue-Based Virtual Screening of Novel Selective Estrogen-Receptor Degraders for Breast Cancer Treatment;Journal of Chemical Information and Modeling;2023-11-23
2. Optimization of small molecule degraders and antagonists for targeting estrogen receptor based on breast cancer: current status and future;Frontiers in Pharmacology;2023-09-21
3. Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity;Journal of Medicinal Chemistry;2023-08-30
4. Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges;Journal of Medicinal Chemistry;2023-06-28
5. Selenium Analogue of LSZ102 as a Highly Potent ER‐α Binder;European Journal of Organic Chemistry;2023-06-14
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3