Rational Substitution of ε-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin-Reference-Cited by-同舟云学术

Rational Substitution of ε-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin

Published:2020-03-16 Issue:7 Volume:63 Page:3522-3537
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mayandi Venkatesh¹²,Xi Qingxiao¹,Leng Goh Eunice Tze¹,Koh Siew Kwan³,Jie Toh Thomas Yong¹,Barathi Veluchamy Amutha¹⁴⁵,Urf Turabe Fazil Mobashar Hussain⁶,Somaraju Chalasani Madhavi Latha⁶,Varadarajan Jayasudha¹,Jeng Ting Darren Shu¹⁷,Beuerman Roger W.¹⁵,Chan Lai Wah⁸,Agrawal Rupesh⁹,Sebastian Barkham Timothy Mark¹⁰,Zhou Lei³⁴⁵,Verma Navin Kumar¹⁶¹¹^ORCID,Lakshminarayanan Rajamani¹⁵⁸^ORCID

Affiliation:

1. Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore

2. School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, 637551, Singapore

3. Ocular Proteomics Laboratory, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore

4. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore

5. Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore

6. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore

7. Academic Ophthalmology, University of Nottingham, Nottingham NG7 2RD, U.K.

8. Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore

9. National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 308433, Singapore

10. Department of Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore

11. Skin Research Institute of Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore

Funder

SingHealth Foundation

Agency for Science, Technology and Research

National Medical Research Council

Strategic Academic Initiative

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01846

Reference67 articles.

1. The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020

2. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

3. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

4. World Health Organization. The Evolving Threat of Antimicrobial Resistance: Options for Action; World Health Organization: Geneva, Switzerland, 2012; pp 1–119.

5. Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Poly-basic peptides and polymers as new drug candidates against Plasmodium falciparum;Malaria Journal;2024-08-01

2. Unconventional fluorescence behavior of ε-polylysine: Selective and sensitive detection of Cu2+ in real water samples, test paper strips, living cells, and anticounterfeiting applications;Sensors and Actuators B: Chemical;2024-06

3. Silver and Antimicrobial Polymer Nanocomplexes to Enhance Biocidal Effects;International Journal of Molecular Sciences;2024-01-19

4. Effect of Air Drying on the Metabolic Profile of Fresh Wild and Artificial Cordyceps sinensis;Foods;2023-12-21

5. Poly-basic peptides and polymers as new drug candidate againstPlasmodium falciparum;2023-09-16