Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein α
Author:
Affiliation:
1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada
Funder
Canadian Institutes of Health Research
McGill University
Fonds de Recherche du Qu?bec - Nature et Technologies
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00642
Reference50 articles.
1. Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
2. The resurgence of covalent drugs
3. Covalent inhibitors design and discovery
4. Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
5. Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family
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