C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure–Activity Relationships

Author:

Roleira Fernanda M. F.12ORCID,Varela Carla12,Amaral Cristina3,Costa Saul C.1,Correia-da-Silva Georgina3,Moraca Federica456,Costa Giosuè46ORCID,Alcaro Stefano46,Teixeira Natércia A. A.3,Tavares da Silva Elisiário J.12ORCID

Affiliation:

1. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal

2. CIEPQPF Centre for Chemical Processes Engineering and Forest Products, University of Coimbra, 3030-790 Coimbra, Portugal

3. UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

4. Laboratorio di Chimica Farmaceutica, Dipartimento di Scienze della Salute, Università Magna Græcia di Catanzaro, 88100 Catanzaro, Italy

5. Department of Pharmacy, University of Naples “Federico II”, via D. Montesano 49, 80131, Naples, Italy

6. Net4Science Academic Spin-Off, “Magna Græcia” University of Catanzaro, “S. Venuta”, Catanzaro, Italy

Funder

Funda??o para a Ci?ncia e a Tecnologia

European Regional Development Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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