Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections-Reference-Cited by-同舟云学术

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Published:2019-11-25 Issue:6 Volume:63 Page:2789-2801
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Bin¹^ORCID,Trout Robert E. Lee¹,Chu Guo-Hua¹,McGarry Daniel¹,Jackson Randy W.¹,Hamrick Jodie C.¹,Daigle Denis M.¹,Cusick Susan M.¹,Pozzi Cecilia²^ORCID,De Luca Filomena³^ORCID,Benvenuti Manuela²^ORCID,Mangani Stefano²^ORCID,Docquier Jean-Denis³^ORCID,Weiss William J.⁴,Pevear Daniel C.¹,Xerri Luigi¹,Burns Christopher J.¹

Affiliation:

1. Venatorx Pharmaceuticals, Inc., 30 Spring Mill Drive, Malvern, Pennsylvania 19355, United States

2. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy

3. Department of Medical Biotechnology, University of Siena, I-53100 Siena, Italy

4. UNT System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107-2699, United States

Funder

U.S. Department of Health and Human Services

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01518

Reference44 articles.

1. Industrial production of β-lactam antibiotics

2. Carbapenemases: the Versatile β-Lactamases