Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders-Reference-Cited by-同舟云学术

Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders

Published:2020-01-20 Issue:3 Volume:63 Page:1068-1083
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bonazzi Simone¹^ORCID,Goold Carleton P.²,Gray Audrey²,Thomsen Noel M.¹,Nunez Jill¹,Karki Rajeshri G.¹^ORCID,Gorde Aakruti²,Biag Jonathan D.²,Malik Hasnain A.¹,Sun Yingchuan¹,Liang Guiqing³,Lubicka Danuta⁴,Salas Sarah²,Labbe-Giguere Nancy¹,Keaney Erin P.¹,McTighe Stephanie²,Liu Shanming⁵,Deng Lin³,Piizzi Grazia¹,Lombardo Franco³,Burdette Doug³,Dodart Jean-Cosme²,Wilson Christopher J.²,Peukert Stefan¹,Curtis Daniel²,Hamann Lawrence G.¹^ORCID,Murphy Leon O.⁵

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States

2. Neuroscience, Novartis Institutes for BioMedical Research, 22 Windsor Street, Cambridge, Massachusetts 02139, United States

3. Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

4. Global Drug Development/Technical Research and Development, Novartis Institutes for BioMedical Research, 700 Main Street, Cambridge, Massachusetts 02139, United States

5. Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01398

Reference29 articles.

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5. Mutations in the mammalian target of rapamycin pathway regulatorsNPRL2andNPRL3cause focal epilepsy

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