Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies-Reference-Cited by-同舟云学术

Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies

Published:2019-11-12 Issue:12 Volume:63 Page:6251-6275
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brown Dean G.¹^ORCID,Smith Graham F.²^ORCID,Wobst Heike J.³

Affiliation:

1. Hit Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

2. Data Science and Artificial Intelligence, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom

3. Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01625

Reference88 articles.

1. Toxicology Strategies for Drug Discovery: Present and Future

2. In Silico Prediction of Chemical Toxicity for Drug Design Using Machine Learning Methods and Structural Alerts

3. Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

4. Secondary pharmacology: screening and interpretation of off-target activities – focus on translation

5. Secondary pharmacology data to assess potential off-target activity of new drugs: a regulatory perspective

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