1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, School of Pharmaceutical Sciences, University of Shizuoka and the GCOE21 Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China, JST, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan, and, Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan