Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging

Author:

Liu Xiao1,Jiang Shuang23,Kong Linghui1,Ye Rongrong34,Xiao Li1,Xu Xuejun3,He Qian1,Wei Yuanyuan5,Li Zixiang1,Sun Huijiao1,Xie Qiong1,Xu Xu4,Lu Yan4,Wang Yujun36,Li Wei1,Fu Wei1ORCID,Qiu Zhuibai1,Liu Jinggen236,Shao Liming17ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

2. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, No. 138, Xianlin Road, Nanjing 210023, China

3. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Collaborative Innovation Center for Brain Science, 555 Zuchongzhi Road, Shanghai 201203, China

4. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China

5. School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, No. 639 Longmian Road, Nanjing 210009, China

6. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China

7. State Key Laboratory of Medical Neurobiology, Fudan University, No. 138 Yixueyuan Road, Shanghai 200032, China

Funder

Youth Innovation Promotion Association of the Chinese Academy of Sciences

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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