Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases

Author:

Krahn Andrea I.1,Wells Carrow23ORCID,Drewry David H.23ORCID,Beitel Lenore K.1ORCID,Durcan Thomas M.1,Axtman Alison D.23ORCID

Affiliation:

1. Early Drug Discovery Unit, Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada H3A 2B4

2. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

3. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Funder

Merck Sharp and Dohme

Merck KGaA

Genentech

Pfizer

Ontario Ministry of Economic Development and Innovation

Innovative Medicines Initiative

Genome Canada

Wellcome Trust

AbbVie

National Institute on Aging

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Amyotrophic Lateral Sclerosis Association

National Institutes of Health

Boehringer Ingelheim

Janssen Pharmaceuticals

Eshelman Institute for Innovation, University of North Carolina

Novartis Pharma

Canada Foundation for Innovation

Takeda Pharmaceutical Company

Pharmaceuticals Bayer

McGill Healthy Brains for Healthy Lives

Ghislaine and Sebastian Van Berkom foundation

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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