Design, Synthesis, and Biological Evaluation of Piperazine and <i>N</i>-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for Alzheimer’s Disease Therapy-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for Alzheimer’s Disease Therapy

Published:2023-05-22 Issue:11 Volume:14 Page:2217-2242
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Waiker Digambar Kumar¹,Verma Akash¹,Akhilesh ¹,A Gajendra T.¹,Singh Namrata²,Roy Anima²,Dilnashin Hagera³,Tiwari Vinod¹^ORCID,Trigun Surendra Kumar²,Singh Surya P.³,Krishnamurthy Sairam¹,Lama Prem⁴^ORCID,Davisson Vincent Jo⁵^ORCID,Shrivastava Sushant Kumar¹^ORCID

Affiliation:

1. Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology−Banaras Hindu University, Varanasi 221005, India

2. Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India

3. Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India

4. CSIR - Indian Institute of Petroleum, Tech. Block, Mohkampur, Dehradun 248005, Uttarakhand, India

5. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 479047, United States

Funder

Science and Engineering Research Board

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00245

Reference74 articles.

1. Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention

2. Alzheimer's Disease: A General Introduction and Pathomechanism

3. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

4. Economic burden of Alzheimer disease and managed care considerations

5. Novel Benzylated (Pyrrolidin-2-one)/(Imidazolidin-2-one) Derivatives as Potential Anti-Alzheimer’s Agents: Synthesis and Pharmacological Investigations

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